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Doctor's Best Best 5-HTP (100 mg), 60 Vegetable Capsules

5-HTP functions as the precursor for serotonin, a monoamine neurotransmitter found in the central nervous system (CNS) and some cells of the digestive tract. In the body, 5-HTP is formed by the addition of a hydroxyl group (–OH) to tryptophan, a reaction catalyzed by the enzyme tryptophan hydroxylase.

This enzyme can be hindered by stress and conditions such as vitamin B6 deficiency, which is one reason B6 is included in this formula. Additionally, pyridoxal phosphate (vitamin B6) is necessary for 5-HTP to be converted to serotonin.

Vitamin C participates in the conversion of tryptophan to 5-HTP and of tyrosine to norepinephrine, another important neurotransmitter. Synthesis of serotonin in the brain requires an adequate supply of either tryptophan or 5-HTP as precursors in the CNS. The supply of tryptophan available for conversion to 5-HTP depends on a number of factors, including the nutritional status of the individual and the competition between tryptophan and other amino acids for transport across the blood-brain barrier. Whereas tryptophan may be sidetracked into the production of niacin or protein, 5-HTP readily crosses the blood-brain barrier and becomes available for serotonin synthesis. Therefore, supplementation with 5-HTP is a more direct route to serotonin production.

5-HTP (5-hydroxy l-tryptophan) is a naturally occurring metabolite of the amino acid tryptophan

  • 5-HTP helps maintain mental and emotional well-being and promotes healthy sleep
  • 5-HTP is extracted from the seeds of the griffonia simplicifolia plant
  • Gluten Free, Non-GMO, Vegan
  • Label images may vary

Suggested Use:
As a dietary supplement, take 1 capsule two or three times daily, with or without food.


Warnings: Not to be used when taking MAO inhibitors, selective serotonin reuptake inhibitors (SSRIs), or other anti-depressant medications. It should also not be used by individuals taking any of the category of medications known as "triptans".


Note: Best 5-HTP is tested to ensure that it does not contain "Peak X".

Supplement Facts
Serving Size: 1 Vegetarian Capsule
Servings per container: 60 servings
Amount Per Serving %DV
5-hydroxy L-tryptophan 100 mg

Other Ingredients: Modified cellulose (veggie cap), rice powder, magnesium stearate (vetetable source).

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